A round flask was charged with 2,4-dichloro-6-(2-chlorophenyl)pyrimidine (150 mg), 2-oxo-2,3-dihydrobenzo[d]oxazol-6-ylboronic acid (104 mg), Pd(dppf)Cl2(15 mg), 1 M NaHCO3 (0.5 mL) and THF (5 mL). The reaction mixture was stirred at 70° C. for 2 hours, then 4 mL of conc. HCl was added. The reaction was heated to 90° C. for 5 hours. The mixture was filtrated, concentrated and purified by prep-HPLC to give the product. 1H NMR (400 MHz, d6-DMSO): δ 11.00 (s, br, 2H), 7.81-7.75 (m, 2H), 7.62-7.43 (m, 3H), 7.12-7.00 (m, 3H). MS (EI) for C17H10ClN3O3: 339 (MH+).
