Acetic Acid → HCID 11594031, 화합물
반응식
O[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH2:9][C:10]([C:12]1[CH:17]=[C:16](OC)[CH:15]=[CH:14][N:13]=1)=[O:11].C[C:22](O)=[O:23]>Cl.O>[CH3:22][O:23][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[O:11][C:2]3[C:3]([C:8](=[O:20])[CH:9]=2)=[CH:4][CH:5]=[CH:6][CH:7]=3)=[N:13][CH:14]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
1-(2-Hydroxy-phenyl)-3-(4-methoxy-pyridin-2-yl)-propane-1,3-dione (870 mg, 3.21 mmol) was dissolved in a mixture of 48% HCl (1 mL) and AcOH (10 mL) and heated at 100° C. for 1 h. The reaction mixture was cooled to rt, diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried and concentrated to give 2-(5-methoxy-pyridin-2-yl)-chromen-4-one (794 mg, 98%).
후처리
- temperatureThe reaction mixture was cooled to rt
- extractionextracted with EtOAc
- washThe organic layer was washed with water, brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a342ad48898b4079b769a2887fc7f270
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08242130B2
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