Acetone → Phenol, 4-(pentafluoroethyl)-

HRID 884941노트

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HRID 884941 반응식
C(OC[O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])=[CH:8][CH:7]=1)C.CC(C)=O.Cl>O>[F:17][C:12]([F:18])([C:9]1[CH:10]=[CH:11][C:6]([OH:5])=[CH:7][CH:8]=1)[C:13]([F:14])([F:16])[F:15]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 866510611-Ethoxymethoxy-4-pentafluoroethyl benzene

생성물 1

HCID 10856782Phenol, 4-(pentafluoroethyl)-

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

7.39 g of 1-ethoxymethoxy-4-pentafluoroethyl benzene, 30 ml of acetone and 30 ml of 6 M hydrochloric acid were stirred while heating at 50° C. for 2.5 hours. The reaction mixture was cooled to room temperature, and then poured into water, followed by extraction with ethyl acetate. The combined organic layers were washed with water and a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 4-(pentafluoroethyl)phenol.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionfollowed by extraction with ethyl acetate
  3. washThe combined organic layers were washed with water
  4. dry with materiala saturated sodium chloride solution, dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f1f6aff8b413487cb590b02096ecdf6a
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242133B2

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