Hydrochloric Acid → 2-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

HRID 885067노트

반응식

HRID 885067 반응식
[OH:1][CH:2]([C:4]1[N:8]=[CH:7][N:6]([C:9]2[N:10]=[CH:11][C:12]([O:25][CH3:26])=[C:13]3[C:17]([C:18](=[O:24])[C:19]([O:21]CC)=[O:20])=[CH:16][NH:15][C:14]=23)[N:5]=1)[CH3:3].C([O-])([O-])=O.[K+].[K+].Cl>CO.O>[OH:1][CH:2]([C:4]1[N:8]=[CH:7][N:6]([C:9]2[N:10]=[CH:11][C:12]([O:25][CH3:26])=[C:13]3[C:17]([C:18](=[O:24])[C:19]([OH:21])=[O:20])=[CH:16][NH:15][C:14]=23)[N:5]=1)[CH3:3]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 58026059ethyl 2-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

생성물 1

HCID 580260672-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid수율 50%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Ethyl 2-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate (100 mg, 0.278 mmol) and K2CO3 (77 mg, 0.557 mmol) were dissolved in MeOH (2 mL) and water (2 mL). The mixture was stirred at room temperature overnight, and neutralized with 1N HCl to pH 3. All solvents were removed and the residue was purified by prep. HPLC to give 2-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid (46 mg, 0.139 mmol, 49.9% yield). LCMS: m/z 332.1 (M+H)+, 1.17 min (method 8).

후처리

  1. customAll solvents were removed
  2. customthe residue was purified by prep

출처 및 근거

ORD 기록
ord-d58bc6c71b0f4e8ab0f6ffcb5bfcfca3
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242124B2

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