(E)-4-(4-Fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester → 4-(4-Fluoro-phenyl)-4-methyl-pentanoic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:17])/[CH:5]=[CH:6]/[C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:2]>CO.[Pt](=O)=O>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH2:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)([CH3:9])[CH3:8])[CH3:2]참가 물질
4
실험 절차
To a solution of (E)-4-(4-fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester (4.10 g) in methanol (150 ml) at room temperature was added platinum(IV) oxide (788 mg). The mixture was stirred under an atmosphere of hydrogen (1 atm) at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to yield a yellow oil, (3.97 g, 96%); MS (ISP): 239.2 ([M+H]+).
후처리
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
- customto yield a yellow oil, (3.97 g, 96%)
출처 및 근거
- ORD 기록
- ord-ac96e20798ce41cdbac5c4b82b4c5d7e
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08242153B2
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