Phosphorus tribromide → [3-(2-Bromomethyl-4-methyl-phenoxy)-phenyl]-acetic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH2:20]O)[CH:7]=1)[CH3:2].P(Br)(Br)[Br:24]>O1CCOCC1>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH2:20][Br:24])[CH:7]=1)[CH3:2]참가 물질
4
실험 절차
To [3-(2-hydroxymethyl-4-methyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.17 g, 0.57 mmol) in 1,4-dioxane was added phosphorus tribromide (0.07 mL, 0.73 mmol), and the reaction was stirred for 1 hour at room temperature. After work-up, 0.1 g of the desired product was obtained.
출처 및 근거
- ORD 기록
- ord-657f036624254159995a9a5be6feb4af
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08242145B2
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