Lithium Hydroxide → {3-[4-Methyl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

HRID 885242노트

반응식

HRID 885242 반응식
C([O:3][C:4](=[O:27])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH2:20][N:21]2[CH2:25][CH2:24][O:23][C:22]2=[O:26])[CH:7]=1)C.[OH-].[Li+]>CO.O>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:27])=[O:3])[CH:11]=[CH:10][CH:9]=2)=[C:14]([CH2:20][N:21]2[CH2:25][CH2:24][O:23][C:22]2=[O:26])[CH:15]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 58237553{3-[4-Methyl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

생성물 1

HCID 44187531{3-[4-Methyl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Hydrolysis of {3-[4-methyl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester with lithium hydroxide in MeOH and H2O at 60° C. provided the desired product.

출처 및 근거

ORD 기록
ord-9ea0ecb008704cab8402b86480ab1794
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

반응 노트

불러오는 중…