홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Phosphorus tribromide → [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]acetic acid methyl ester

HRID 885249
노트
인쇄 미리보기

반응식

HRID 885249 반응식
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19]O)[CH:6]=1.P(Br)(Br)[Br:23].C([O-])(O)=O.[Na+]>COCCOC>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][Br:23])[CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 24614Phosphorus tribromideHCID 516892Sodium BicarbonateHCID 58237523[3-(4-Bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid methyl ester

생성물 1

HCID 58237479[3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]acetic acid methyl ester수율 85.2%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

To [3-(4-bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid methyl ester (3 g, 8.5 mmol) in DME (30 mL) under N2 was added phosphorus tribromide (1.2 mL, 12.8 mmol), and the reaction was stirred at room temperature for 6 hours. The solution was cooled to 0° C. and adjusted to pH 6 with saturated aqueous NaHCO3, and the mixture was extracted with EtOAc. The crude material was purified by silica gel chromatography to give the desired product as a colorless oil (3 g).

후처리

  1. temperatureThe solution was cooled to 0° C.
  2. extractionthe mixture was extracted with EtOAc
  3. customThe crude material was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-82243b7214c94865921dfb310eda662e
출처 데이터셋
uspto-grants-2012_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08242145B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트