2-(3-Methoxyphenyl)propanoic acid → 2-(3-Hydroxyphenyl)propionic acid, (+-)-

HRID 885257노트

반응식

HRID 885257 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1>Br.C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 1

HCID 5854292-(3-Methoxyphenyl)propanoic acid

생성물 1

HCID 124468532-(3-Hydroxyphenyl)propionic acid, (+-)-

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

반응 조건

온도
100 °C

실험 절차

2-(3-Methoxy-phenyl)-propionic acid (0.1 g, 0.55 mmol) was dissolved in a mixture of hydrogen bromide (2 mL) and acetic acid (2 mL) and heated to 100° C. overnight. The mixture was partitioned between H2O and EtOAc, and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the desired product.

후처리

  1. customThe mixture was partitioned between H2O and EtOAc
  2. extractionthe aqueous layer was extracted with EtOAc
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-009e52aca744482aaee07a56988fc909
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

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