Sodium borohydride → [5-(4-Bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH:20]=[O:21])[CH:9]=[CH:8][C:7]=1[Cl:22])[CH3:2].[BH4-].[Na+]>CO>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20][OH:21])[CH:9]=[CH:8][C:7]=1[Cl:22])[CH3:2]참가 물질
4
실험 절차
To [5-(4-bromo-2-formyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester (0.3 g, 0.76 mmol) in MeOH (20 mL) was added sodium borohydride (0.03 g, 0.78 mmol), and the mixture was stirred at room temperature for 10 minutes. The mixture was worked-up to give the desired product (0.3 g).
출처 및 근거
- ORD 기록
- ord-d5ea3a48f0ae4068b5f8a59bf610fcec
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08242145B2
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