Methanol → {4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

HRID 885378노트

반응식

HRID 885378 반응식
C([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[CH:17][C:16]=2[CH2:27][N:28]2[CH2:32][CH2:31][O:30][C:29]2=[O:33])[CH:7]=1)C.CO.[OH-].[Li+]>O>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][C:4]([OH:34])=[O:3])=[CH:7][C:8]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)=[CH:17][C:16]=1[CH2:27][N:28]1[CH2:32][CH2:31][O:30][C:29]1=[O:33]

참가 물질

5

반응물 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 58237477{4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

생성물 1

HCID 44187533{4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

{4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (0.43 mmol) ini MeOH and H2O was treated with lithium hydroxide, and the reaction was stirred at 60° C. for 20 minutes. The mixture was acidified and concentrated, and the reside was purified by preparative HPLC to give the title compound.

후처리

  1. concentrationconcentrated
  2. customthe reside was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-30c719c05ffb4a22b7aa3dd3e4e3a7e1
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

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