1-Methylpiperazine → 1-(6-Chloropyridin-3-yl)-4-methylpiperazine

HRID 885951노트

반응식

Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Cl:8][C:5]1[N:6]=[CH:7][C:2]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)=[CH:3][CH:4]=1

참가 물질

반응물 2

HCID 531671-Methylpiperazine

HCID 27344145-Bromo-2-chloropyridine

생성물 1

HCID 753557481-(6-Chloropyridin-3-yl)-4-methylpiperazine

실험 절차

The title compound was prepared from 5-bromo-2-chloropyridine and 1-methylpiperazine according to Method BG and was isolated as a brown oil (27%). LCMS (ES+) 212.0 (M+H)+, RT 1.97 minutes (70% purity) (Method 2).

출처 및 근거

ORD 기록: ord-ca10648444af454897bc959cea819a07
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08242116B2

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