2,6-Dichlorobenzoyl chloride → 5-Amino-N-(2-{[[(2,6-dichlorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

HRID 886718노트

반응식

HRID 886718 반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:14]([NH:16][CH2:17][C:18]([OH:26])([CH2:23][NH:24][CH3:25])[C:19]([F:22])([F:21])[F:20])=[O:15].C(N(C(C)C)CC)(C)C.[Cl:36][C:37]1[CH:45]=[CH:44][CH:43]=[C:42]([Cl:46])[C:38]=1[C:39](Cl)=[O:40]>O1CCCC1>[C:18]([O-:26])(=[O:40])[CH3:23].[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)[N:5]=[CH:4][C:3]=1[C:14]([NH:16][CH2:17][C:18]([CH2:23][N:24]([C:39]([C:38]1[C:37]([Cl:36])=[CH:45][CH:44]=[CH:43][C:42]=1[Cl:46])=[O:40])[CH3:25])([OH:26])[C:19]([F:22])([F:21])[F:20])=[O:15]

참가 물질

6

반응물 3

HCID 783922,6-Dichlorobenzoyl chlorideHCID 81531DiisopropylethylamineHCID 594874925-Amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide

생성물 2

HCID 175AcetateHCID 594875115-Amino-N-(2-{[[(2,6-dichlorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide수율 135.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide (56 mg, 0.15 mmol) in anhydrous tetrahydrofuran (2 ml) cooled in ice was added diisopropylethylamine (0.052 ml, 0.3 mmol) followed by 2,6-dichlorobenzoyl chloride (0.023 ml, 0.164 mmol). After 20 minutes, the mixture was removed from the ice and left at 21° C. for 19 hours. The mixture was blown down, the residue was dissolved in dichloromethane (3 ml) and washed with 2M hydrochloric acid (1 ml) and water (1 ml). It was again blown down and purified on a 5 g SPE cartridge, eluting with dichloromethane and then mixtures of cyclohexane/ethyl:acetate (10:1), (5:1), (3:1) and finally (2:1) to give the title compound (55.6 mg).

후처리

  1. customthe mixture was removed from the ice
  2. waitleft at 21° C. for 19 hours
  3. dissolutionthe residue was dissolved in dichloromethane (3 ml)
  4. washwashed with 2M hydrochloric acid (1 ml) and water (1 ml)
  5. custompurified on a 5 g SPE cartridge
  6. washeluting with dichloromethane

출처 및 근거

ORD 기록
ord-409c5855d36b4265bc02e23118123bea
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247377B2

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