Hydrochloric Acid → HCID 57420173, 화합물

HRID 887062노트

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HRID 887062 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:11][CH2:10]1.[ClH:32]>ClCCl.C(OCC)C>[ClH:32].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][C:18]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]3)=[CH:23][CH:22]=2)=[O:19])[CH2:13][CH2:14]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57420171HCID 57420171, 화합물

생성물 1

HCID 57420173HCID 57420173, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of the 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-(4-(methoxy-phenyl)piperazin-1-yl)butanoate (19a) (0.1 g) in 2 mL dichloromethane was added 4 mL 2M HCl solution in diethyl ether. The mixture was stirred at room temperature for 30 minutes. The solvent was evaporated, residue was triturated with ether, and solid precipitated was filtered, washed with ether and dried to give 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate hydrochloride 20a. The hydrochloride salt 20a gave satisfactory 1H NMR spectral data. White solid, 0.106 g (98%). MS (ESI): m/z=424.1 (M+H+).

후처리

  1. customThe solvent was evaporated
  2. customresidue was triturated with ether, and solid
  3. customprecipitated
  4. filtrationwas filtered
  5. washwashed with ether
  6. customdried

출처 및 근거

ORD 기록
ord-b6852d15c935475f87e9f726bcd361e7
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247420B2

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