Phosgene → 3-Chloro-5-isocyanatoisoquinoline

HRID 887265

반응식

HRID 887265 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([Cl:12])[N:6]=[CH:7]2.[C:13](Cl)(Cl)=[O:14]>C1(C)C=CC=CC=1.C(N(CC)CC)C>[Cl:12][C:5]1[N:6]=[CH:7][C:8]2[C:3]([CH:4]=1)=[C:2]([N:1]=[C:13]=[O:14])[CH:11]=[CH:10][CH:9]=2

참가 물질

5

반응물 2

HCID 6371PhosgeneHCID 167490403-Chloroisoquinolin-5-amine

생성물 1

HCID 223376853-Chloro-5-isocyanatoisoquinoline

시약·촉매·용매 2

HCID 1140Toluene용매2회HCID 8471Triethylamine용매

실험 절차

5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. concentrationwas then concentrated in vacuo
  3. customused in the next step without further purification

출처 및 근거

ORD 기록
ord-6c33b8c267a94638be4665ad47409470
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247413B2

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