Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide

반응식

[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 311869Isoquinolin-3-Amine

생성물 1

HCID 12366594N-(Isoquinolin-3-yl)acetamide

실험 절차

3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.

후처리

concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-fc92afb6bdd2453ab5fb523762a690c5
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247413B2

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