Hydrochloric Acid → 4-Methylpiperidin-4-ol hydrochloride

HRID 887394노트

반응식

HRID 887394 반응식
[OH:1][C:2]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:16].C(OCC)C>>[ClH:16].[CH3:15][C:2]1([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 227308121-Boc-4-methyl-piperidin-4-OL

생성물 1

HCID 219492954-Methylpiperidin-4-ol hydrochloride

실험 절차

To tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (1.0 g, 4.6 mmol) was added hydrogen chloride, 1.0 M solution in diethyl ether (4.6 ml, 4.6 mmol). The reaction mixture was stirred at RT for 4 h. The reaction mixture was concentrated down to give a yellow oil which was used directly in the following step.

후처리

  1. concentrationThe reaction mixture was concentrated down
  2. customto give a yellow oil which

출처 및 근거

ORD 기록
ord-168fa7a3fb4f4640b30f18efaaea8d50
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247418B2

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