Hydrochloric Acid → 2-(8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride

반응식

[NH2:1][CH2:2][CH2:3][CH:4]1[C:8]2[C:9]3[N:10]([N:13]=[CH:14][C:15]=3C(OCC)=O)[CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5]1.[ClH:21]>>[ClH:21].[CH:15]1[CH:14]=[N:13][N:10]2[CH:11]=[CH:12][C:7]3[CH2:6][CH2:5][CH:4]([CH2:3][CH2:2][NH2:1])[C:8]=3[C:9]=12

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 59145841ethyl 9-(2-aminoethyl)-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate

생성물 1

HCID 686989162-(8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride수율 99%

반응 조건

온도: 110 °C

실험 절차

A mixture of ethyl 9-(2-aminoethyl)-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (105 mg, 0.384 mmol) in 12M hydrochloric acid (4 mL) was stirred at 110° C. for 14 hr, and concentrated under reduced pressure to give the title compound (91.1 mg, yield 99%).

후처리

concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-1749d3fff6284c948d5d28fb15940750
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247429B2

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