Butyrohydrazide → HCID 21914092, 화합물

HRID 887931노트

반응식

HRID 887931 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13](=S)[NH2:14])(=[O:3])[CH3:2].[C:16]([NH:21][NH2:22])(=O)[CH2:17][CH2:18][CH3:19]>C(O)CCC>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13]1[N:14]=[C:16]([CH2:17][CH2:18][CH3:19])[NH:21][N:22]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 77079ButyrohydrazideHCID 219141121-Acetyl-2,3-dihydro-1H-indole-2-carbothioamide

생성물 1

HCID 21914092HCID 21914092, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A suspension of intermediate (13) (0.0102 mole) in n-butanol (200 ml) was treated with butanoic acid hydrazide (0.0254 mole), stirred for 10 minutes, and then heated to reflux for 10 days. The reaction was cooled, concentrated in vacuo, distributed between DCM and distilled water. The concentrated organic phase was subjected to reverse phase preparatory column chromatography to give 1-acetyl-2,3-dihydro-2-(5-propyl-1H-1,2,4-triazol-3-yl)-1H-indole (compound 91).

후처리

  1. temperatureheated
  2. temperatureto reflux for 10 days
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. distillationdistilled water

출처 및 근거

ORD 기록
ord-1af4cf5e9c1e45a485af3af8555c6dd8
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247432B2

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