Sodium Hydroxide → HCID 21914127, 화합물

HRID 887932노트

반응식

HRID 887932 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13]1[N:17]=[C:16]([CH2:18][CH2:19][CH3:20])[NH:15][N:14]=1)(=O)C.[OH-].[Na+]>C(O)C.C(OCC)(=O)C>[CH2:18]([C:16]1[NH:15][N:14]=[C:13]([CH:5]2[CH2:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4]2)[N:17]=1)[CH2:19][CH3:20]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 21914092HCID 21914092, 화합물

생성물 1

HCID 21914127HCID 21914127, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of the compound 91 (0.42 g) in ethanol (25 ml) was treated with an aqueous NaOH solution (3 M, 25 mL) and the reaction mix was refluxed for 24 hours. The reaction was cooled, diluted with ethyl acetate, and treated with cold distilled water. The layers were separated and the aqueous fraction was extracted 5 times with ethyl acetate and the combined organic fractions were dried, concentrated and purified by preparatory column chromatography yielding 2,3-dihydro-2-(5-propyl-1H-1,2,4-triazol-3-yl)-1H-indole.

후처리

  1. additionthe reaction mix
  2. temperaturewas refluxed for 24 hours
  3. temperatureThe reaction was cooled
  4. additiontreated
  5. distillationwith cold distilled water
  6. customThe layers were separated
  7. extractionthe aqueous fraction was extracted 5 times with ethyl acetate
  8. customthe combined organic fractions were dried
  9. concentrationconcentrated
  10. custompurified by preparatory column chromatography

출처 및 근거

ORD 기록
ord-8f289a655286477cba3d088e1160d624
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247432B2

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