Hydrochloric Acid → [4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-yl)-phenyl]-acetonitrile

HRID 888589노트

반응식

HRID 888589 반응식
[CH3:1][C:2]1[N:6](C2CCCCO2)[N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[C:3]=1[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]#[N:25])=[CH:19][CH:18]=1.Cl>C(OCC)(=O)C>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[C:3]=1[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]#[N:25])=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59331959{4-[5-Methyl-1-(tetrahydro-pyran-2-yl)-3-trifluoromethyl-1H-pyrazol-4-yl]-phenyl}-acetonitrile

생성물 1

HCID 59331945[4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-yl)-phenyl]-acetonitrile

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To {4-[5-Methyl-1-(tetrahydro-pyran-2-yl)-3-trifluoromethyl-1H-pyrazol-4-yl]-phenyl}-acetonitrile (Example 8B) (35 mg, 0.1 mmol, 1.0 equiv) in ethyl acetate (1 ml) was added HCl in ethyl acetate (1 ml) and the mixture was stirred for 1 hour.

출처 및 근거

ORD 기록
ord-5bde854437c04ff49109f868fae6cd29
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247576B2

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