Phenol → 1-[3-(4-Bromo-phenyl)-3-phenoxy-propyl]-1H-imidazole

반응식

[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15](O)[CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[CH:11][CH:10]=1>>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 996Phenol

HCID 214153621-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol

생성물 1

HCID 593319531-[3-(4-Bromo-phenyl)-3-phenoxy-propyl]-1H-imidazole

실험 절차

Phenol was reacted with 1-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol* following the procedure set out in Example 48B to give the title compound. LC/MS: (PS-A2) Rt 2.30 [M+H]+ 357.26, 359.27.

출처 및 근거

ORD 기록: ord-42926d2e8a4e4f35a3632172997350bf
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247576B2

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