Water → 2-Bromo-3-Dodecylthiophene

HRID 888671

반응식

HRID 888671 반응식
[Br:1]N1C(=O)CCC1=O.[CH2:9]([C:21]1[CH:25]=[CH:24][S:23][CH:22]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].O>CN(C=O)C>[Br:1][C:22]1[S:23][CH:24]=[CH:25][C:21]=1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 27336553-Dodecylthiophene

생성물 1

HCID 104268162-Bromo-3-Dodecylthiophene수율 94.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A solution of N-bromosuccinimide (NBS) (48 g; 0.27 mol) dissolved in DMF (160 ml) was slowly added to a solution of 3-dodecylthiophene (68 g; 0.27 mol) dissolved in DMF (110 ml). After the reaction solution was stirred for one day, 750 ml of water was added thereto. An organic material was extracted by using ethyl ether (3×300 ml), and washed with brine and water, and then the residual moisture was removed over anhydrous magnesium sulfate. After removing the solvent, the residue was distilled off under reduced pressure at 125° C./˜5 mmHg to obtain a product (84.85 g, yield of 94%).

후처리

  1. extractionAn organic material was extracted
  2. washwashed with brine and water
  3. customthe residual moisture was removed over anhydrous magnesium sulfate
  4. customAfter removing the solvent
  5. distillationthe residue was distilled off under reduced pressure at 125° C./˜5 mmHg

출처 및 근거

ORD 기록
ord-d6b1d8f212a7483c997e2a070f30aa84
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247803B2

연결된 노트

불러오는 중…