Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1)
반응식
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1참가 물질
5
실험 절차
Add 4N HCl in 1,4-dioxane (86.096 mmoles, 21.524 mL) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (8.610 mmoles, 2.000 g) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate under reduced pressure to afford the title compound (8.679 mmoles, 1.780 g). MS (m/z): 133 (M+1).
후처리
- concentrationConcentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-5543a4f165984544ae9b5d9454787701
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08252798B2
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