1,2-Dibromoethane → (3R)-4-(2-chloro-6-(1-(S-methylsulfonimidoyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

HRID 888989

반응식

HRID 888989 반응식
[OH-].[Na+].[Cl:3][C:4]1[N:9]=[C:8]([CH2:10][S:11]([CH3:20])(=[O:19])=[N:12]C(=O)C(F)(F)F)[CH:7]=[C:6]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][C@H:22]2[CH3:27])[N:5]=1.Br[CH2:29][CH2:30]Br>[Br-].C([N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC)CCCCCCC.CN1C2C(N=C(N)NC=2NCC1CNC1C=CC(C(NC(C(O)=O)CCC(O)=O)=O)=CC=1)=O>[Cl:3][C:4]1[N:5]=[C:6]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][C@H:22]2[CH3:27])[CH:7]=[C:8]([C:10]2([S:11]([CH3:20])(=[NH:12])=[O:19])[CH2:30][CH2:29]2)[N:9]=1

참가 물질

6

반응물 3

HCID 78391,2-Dibromoethane2회HCID 14798Sodium HydroxideHCID 86660215N-[({2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl]methyl)(methyl)oxido-lambda6-sulfanylidene]-2,2,2-trifluoroacetamide

생성물 1

HCID 86660214(3R)-4-(2-chloro-6-(1-(S-methylsulfonimidoyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine수율 66.1%

시약·촉매·용매 2

HCID 2734117Tetraoctylammonium bromide촉매HCID 178479889HCID 178479889, 화합물용매2회

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온도
20 °C

실험 절차

Sodium hydroxide (Sigma-Aldrich 415413, d=1.515 g/ml, 217 ml of a 50% solution, 4059.84 mmol) was added to N-[({2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}methyl)(methyl)oxido-λ6-sulfanylidene]-2,2,2-trifluoroacetamide (27.12 g, 67.66 mmol), 1,2-dibromoethane (23.32 ml, 270.66 mmol) and tetraoctylammonium bromide (3.70 g, 6.77 mmol) in methyl THF (1000 ml) at 20° C. under nitrogen. The resulting mixture was stirred at 20° C. for 24 hours. Further 1,2-dibromoethane (23.32 ml, 270.66 mmol) was added and the mixture was stirred at 20° C. for a further 24 hours. The reaction mixture was diluted with methyl THF (1000 ml) and the aqueous layer separated. The organic layer was diluted further with EtOAc (1000 ml) and washed with water (1500 ml). The organic layer was dried over MgSO4, filtered and then evaporated. The residue was purified by flash chromatography on silica, eluting with a gradient of 0 to 5% MeOH in DCM. Pure fractions were evaporated to afford (3R)-4-(2-chloro-6-(1-(S-methylsulfonimidoyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine (14.80 g, 66%); 1H NMR (400 MHz, DMSO-d6) 1.21 (3H, d), 1.39 (3H, m), 1.62-1.71 (1H, m), 3.01 (3H, s), 3.43 (1H, tt), 3.58 (1H, dd), 3.72 (1H, d), 3.82 (1H, d), 3.93 (1H, dd), 4.01 (1H, s), 4.38 (1H, s), 6.96 (1H, d); m/z: (ES+) MH+, 331.46 and 333.

후처리

  1. stirringthe mixture was stirred at 20° C. for a further 24 hours
  2. customthe aqueous layer separated
  3. additionThe organic layer was diluted further with EtOAc (1000 ml)
  4. washwashed with water (1500 ml)
  5. dry with materialThe organic layer was dried over MgSO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue was purified by flash chromatography on silica
  9. washeluting with a gradient of 0 to 5% MeOH in DCM
  10. customPure fractions were evaporated

출처 및 근거

ORD 기록
ord-5857ea5c590742f9b91d51af3eb2b17b
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252802B2

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