Sodium Cyanide → 2-(2-Methylpyridin-3-yl)acetonitrile
반응식
Cl[CH2:2][C:3]1[C:4]([CH3:9])=[N:5][CH:6]=[CH:7][CH:8]=1.[C-:10]#[N:11].[Na+].[Cl-].[NH4+]>CN(C=O)C>[CH3:9][C:4]1[C:3]([CH2:2][C:10]#[N:11])=[CH:8][CH:7]=[CH:6][N:5]=1참가 물질
5
반응 조건
- 온도
- 45 °C
실험 절차
970 mg (6.85 mmol) of the compound from Example 37A are initially introduced into 10 ml DMF, 336 mg (6.85 mmol) sodium cyanide are added and the mixture is stirred overnight at 45° C. The reaction mixture is introduced on to 75 ml saturated ammonium chloride solution and extracted several times with methylene chloride. The combined organic phases are dried over sodium sulfate, filtered and concentrated. The residue is purified by means of flash chromatography on silica gel (mobile phase: methylene chloride/methanol 20:1).
후처리
- additionare added
- extractionextracted several times with methylene chloride
- dry with materialThe combined organic phases are dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
- customThe residue is purified by means of flash chromatography on silica gel (mobile phase: methylene chloride/methanol 20:1)
출처 및 근거
- ORD 기록
- ord-3b8056ed72f54a7daab4e4e314dd8c78
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08252817B2
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