p-Trifluoromethylpropiophenone → 1-[4-(Trifluoromethyl)phenyl]propan-1-ol

HRID 889712

반응식

HRID 889712 반응식
[CH3:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[F:12][C:11]([F:13])([F:14])[C:8]1[CH:7]=[CH:6][C:5]([CH:3]([OH:4])[CH2:2][CH3:1])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 136554p-TrifluoromethylpropiophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 53144151-[4-(Trifluoromethyl)phenyl]propan-1-ol수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 4-trifluoromethylpropiophenone (1.0 g, 5.0 mmol) in MeOH (25 mL, 0.20 M), was added NaBH4 (187 mg, 5,0 mmol). After 3 hours at RT, the reaction was concentrated in vacuo, partitioned between H2O and CH2Cl2, dried, filtered and concentrated to give the title compound as a white solid (0.97 g, 96%). 1H NMR (300 MHz, CHLOROFORM-D) δ ppm 0.93 (t, J=7.54 Hz, 3 H) 1.71-1.85 (m, 2 H) 1.85-1.92 (m, 1 H) 4.69 (td, J=6.41, 3.39 Hz, 1 H) 7.44-7.50 (m, 2 H) 7.61 (d, J=8.29 Hz, 2 H).

후처리

  1. concentrationthe reaction was concentrated in vacuo
  2. custompartitioned between H2O and CH2Cl2
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-045a68f696b5460f89ce990f58445a9a
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252935B2

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