Ethanol → Pactimibe

HRID 889789노트

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HRID 889789 반응식
[CH2:1]([N:9]1[C:17]2[C:12](=[C:13]([CH3:29])[C:14](OCC)=[C:15]([CH3:25])[C:16]=2[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:11][CH:10]1CC(O)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-:34].[Na+].[CH3:36][CH2:37][OH:38]>O>[CH2:1]([N:9]1[C:17]2[C:12](=[C:13]([CH3:29])[C:14]([CH2:36][C:37]([OH:34])=[O:38])=[C:15]([CH3:25])[C:16]=2[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:11][CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 69629575N-(1-octyl-5-ethoxycarboxymethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

생성물 1

HCID 3081927Pactimibe

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

N-(1-octyl-5-ethoxycarboxymethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide (3.5 g) was dissolved in EtOH (50 ml) and a solution of NaOH (1.6 g) in water (20 ml) was added, which was followed by stirring at 60° C. for 1 hr. EtOH was evaporated under reduced pressure. The residue was dissolved in water (20 ml) and the mixture was washed with AcOEt (20 ml). The aqueous layer was neutralized with 2N-hydrochloric acid and extracted with AcOEt (50 ml). The AcOEt layer was washed with saturated brine and dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure to give 2.4 g of the title compound.

후처리

  1. customEtOH was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water (20 ml)
  3. washthe mixture was washed with AcOEt (20 ml)
  4. extractionextracted with AcOEt (50 ml)
  5. washThe AcOEt layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customAcOEt was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-1298b7f2e77c472697c01440f23c54c0
출처 데이터셋
uspto-grants-2006_02
특허 번호
USRE038970E1

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