Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 889871

반응식

HRID 889871 반응식
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C)C=O>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl Chloride2회HCID 27569594-Bromo-2,2-diphenylbutyric acid

생성물 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

4-Bromo-2,2-diphenylbutyric acid (Compound B(1), 23 g, 72 mmol) was suspended in 150 mL of chloroform, and 20 mL of thionyl chloride (270 mmol) was added dropwise. After addition of the thionyl chloride, 0.2 mL of dimethylformamide was added and the resulting solution heated at reflux for about 4 h. The reaction mixture was then concentrated under reduced pressure to provide 4-bromo-2,2-diphenylbutyric chloride (Compound D(1)) as a pale yellow oil that was used in the following step without further purification.

후처리

  1. additionwas added
  2. temperaturethe resulting solution heated
  3. temperatureat reflux for about 4 h
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b0821871a2314e6695b0528c5606f54e
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995168B2

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