2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 22249950, 화합물

HRID 890212노트

반응식

HRID 890212 반응식
C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N.[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:36][CH3:37])[CH2:34][CH3:35])[CH2:31][CH2:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12>C(Cl)Cl>[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[CH:31]=[CH:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12

참가 물질

4

반응물 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 22249795HCID 22249795, 화합물

생성물 1

HCID 22249950HCID 22249950, 화합물수율 68.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

DDQ (33 mg, 0.15 mmol) was added to a solution of 3-(3-bromobenzo[b]furan-2-yl)-8-(1-ethylpropyl)-2,5-dimethyl-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine (60 mg, 0.13 mmol) in methylene chloride (10 mL) at room temperature, followed by stirring for one hour. After overnight, the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (40 mg) as a reddish brown oil.

후처리

  1. waitAfter overnight
  2. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-0294b9c7078e4a1fa7c5f5804ffe0332
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995163B2

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