2-Ethylcyclohexanone → 2-Ethyl-1-(hydroxyimino)cyclohexane

HRID 890364

반응식

HRID 890364 반응식
[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=O)[CH3:2].C([O-])(=O)C.[Na+].Cl.[NH2:16][OH:17]>O.C(O)C>[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[N:16][OH:17])[CH3:2]

참가 물질

6

반응물 3

HCID 204742-EthylcyclohexanoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 5746222-Ethyl-1-(hydroxyimino)cyclohexane수율 52%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

To a solution of 2-ethylcyclohexanone (104.3 mmol) in water and ethanol, and sodium acetate (125.1 mmol) were added hydroxylamine hydrochloride (156.4 mmol), the reaction was heated at 70° C. overnight. The ethanol was removed under reduced pressure, and the reaction mixture was dissolved in water. The aqueous layer was extracted with ether, and the combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated to give 2-ethyl-1-(hydroxyimino)cyclohexane (52%) as a thick oil.

후처리

  1. customThe ethanol was removed under reduced pressure
  2. dissolutionthe reaction mixture was dissolved in water
  3. extractionThe aqueous layer was extracted with ether
  4. washthe combined organic extracts were washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-36d1fda336bd4efbb943c938ef9c8884
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995269B2

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