Sodium borohydride → (6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

HRID 890452노트

반응식

HRID 890452 반응식
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH:16]=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[BH4-].[Na+]>CCO>[F:19][C:2]([F:1])([F:18])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 219356276-[4-(Trifluoromethoxy)phenyl]-3-pyridinecarbaldehyde

생성물 1

HCID 21935933(6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6-(4-Trifluoromethoxy-phenyl)-pyridine-3-carbaldehyde (2.0 g, 7.48 mmol) was dissolved in EtOH (37 ml) and treated at 0° C. with NaBH4 (0.28 g, 7.48 mmol). After 10 min the cooling bath was removed and stirring was continued at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents afforded 2.08 g (7.7 mmol, quant.) of the title compound as off-white solid of mp. 57–58° C.

후처리

  1. customAfter 10 min the cooling bath was removed
  2. customwas continued at ambient temperature
  3. additionPouring
  4. extractionice, twofold extraction with AcOEt
  5. washwashing with water
  6. dry with materialdrying over sodium sulfate, and evaporation of the solvents

출처 및 근거

ORD 기록
ord-7bc585eb9922453aa15e6d53fae9c526
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995263B2

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