Lithium Hydroxide → 1h-Indole-1-acetic acid,4-[2-[2-methyl-6-[4-(trifluoromethyl)phenyl]-3-pyridinyl]ethoxy]-
반응식
C([O:3][C:4](=[O:35])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][CH2:16][CH2:17][C:18]3[C:19]([CH3:34])=[N:20][C:21]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[CH:22][CH:23]=3)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:34][C:19]1[C:18]([CH2:17][CH2:16][O:15][C:10]2[CH:11]=[CH:12][CH:13]=[C:14]3[C:9]=2[CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:35])=[O:3])=[CH:23][CH:22]=[C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]([F:32])([F:31])[F:33])=[CH:28][CH:29]=2)[N:20]=1참가 물질
3
실험 절차
In analogy to the procedure described in example 5 g], (4-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid ethyl ester was treated with LiOH to obtain the title compound as white solid.
출처 및 근거
- ORD 기록
- ord-40e9bd05312a4258b076ab1593616cce
- 출처 데이터셋
- uspto-grants-2006_02