Diethyl Ether → HCID 21866824, 화합물
반응식
CCOCC.[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([C:23](OCC)=[O:24])[C:18](OCC)=[O:19].[OH-].[Na+]>O.O1CCCC1>[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH2:23][OH:24])[CH2:18][OH:19]참가 물질
7
실험 절차
To 214 ml of dry ether was added 8 g of lithium aluminium hydride, and a solution of 26.7 g of diethyl (4-chlorobutyl)malonate/53 ml of dry ether was added dropwise with stirring under ice-cooling. After 1-hour-stirring at room temperature, the mixture was cooled with ice-cold water, and 173 ml of tetrahydrofuran/14.7 ml of water was added gradually. Then, 14.7 ml of 1N sodium hydroxide solution and 35 ml of water were added, stirred for 15 minutes, filtrated to remove insolubles. The filtrate was concentrated to provide 18.2 g of the objective compound as colorless oil.
후처리
- temperaturecooling
- stirringAfter 1-hour-stirring at room temperature
- additionwas added gradually
- stirringstirred for 15 minutes
- filtrationfiltrated
- customto remove insolubles
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-2ce3f3250e744176b824c78c02a0632a
- 출처 데이터셋
- uspto-grants-2006_02
- 특허 번호
- US06998412B2
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