Hydrazine hydrate (1:1) → N-(1-(3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)acetamide

HRID 890694

반응식

HRID 890694 반응식
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][C:13]([NH2:15])=[NH:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].O.[NH2:17]N.[C:19]([NH:22][CH:23]([CH3:31])[C:24](=O)[C:25](OCC)=[O:26])(=[O:21])[CH3:20]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:12][C:13]1[NH:15][C:25](=[O:26])[C:24]([CH:23]([NH:22][C:19](=[O:21])[CH3:20])[CH3:31])=[N:17][N:14]=1

참가 물질

4

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 22245807Ethyl 3-acetamido-2-oxobutanoateHCID 222458132-(3,4-Dimethoxyphenyl)ethanimidamide hydrochloride

생성물 1

HCID 135697918N-(1-(3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)acetamide

실험 절차

Analogously to Example 7A, 20.0 g (86.7 mmol) of 2-(3,4-dimethoxyphenyl)ethanamidine hydrochloride (Example 5A) are reacted with 5.21 g (104 mmol) of hydrazine hydrate and 24.3 g (130 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate (Example 6A) to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

출처 및 근거

ORD 기록
ord-4ee6ace81bc449eb9b4a983a9986615a
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06998402B2

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