Phosphorus oxychloride → 7-(1-acetylhexyl)-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
반응식
[C:1]([CH:4]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:5]([NH:7][CH:8]([C:10]1[C:11](=[O:25])[NH:12][C:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[N:14][N:15]=1)[CH3:9])=O)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:4]([C:5]1[N:15]2[C:10]([C:11](=[O:25])[NH:12][C:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)=[N:14]2)=[C:8]([CH3:9])[N:7]=1)[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])(=[O:3])[CH3:2]참가 물질
3
실험 절차
Analogously to Example 1, 340 mg (0.82 mmol) of 2-acetyl-N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}heptanamide (Example 26A) and 540 g (3.50 mmol) of phosphorus oxychloride are reacted to give 7-(1-acetylhexyl)-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.
출처 및 근거
- ORD 기록
- ord-fa6449af3a3b4961ad3b095193ccd804
- 출처 데이터셋
- uspto-grants-2006_02