Lithium Hydroxide → {3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid

HRID 891190노트

반응식

HRID 891190 반응식
C[O:2][C:3](=[O:26])[CH2:4][N:5]1[CH2:11][CH:10]=[CH:9][CH2:8][CH:7]([NH:12][C:13]([C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][N:16]=2)=[O:14])[C:6]1=[O:25].[Li+].[OH-]>C1COCC1.O>[C:15]1([C:13]([NH:12][CH:7]2[CH2:8][CH:9]=[CH:10][CH2:11][N:5]([CH2:4][C:3]([OH:26])=[O:2])[C:6]2=[O:25])=[O:14])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][N:16]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 23598688{3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid methyl ester

생성물 1

HCID 23598657{3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

A solution of {3-[(isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid methyl ester, 4, (330 mg, 0.9 mmol) in 3:1 THF/H2O is treated with excess LiOH (360 mg, 8.6 mmol) and stirred for 2.5 hours at room temperature. The solution is then acidified and the aqueous layer extracted with EtOAc. The EtOAc layer is dried (MgSO4) and concentrated in vacuo to afford the desired product.

후처리

  1. extractionthe aqueous layer extracted with EtOAc
  2. dry with materialThe EtOAc layer is dried (MgSO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9c5514792bd54bc89457262b84e5ef7c
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07001899B2

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