Hydrochloric Acid → Sarcosine p-nitrobenzyl ester hydrochloride

HRID 891693노트

반응식

HRID 891693 반응식
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([CH2:8][O:9][C:10](=[O:21])[CH2:11][N:12](C(OC(C)(C)C)=O)[CH3:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:24].C(OCC)C>O1CCOCC1>[ClH:24].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10](=[O:21])[CH2:11][NH:12][CH3:13])=[CH:22][CH:23]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69544076(N-t-butoxycarbonyl-N-methyl-amino)acetic acid p-nitrobenzyl ester

생성물 1

HCID 69544074Sarcosine p-nitrobenzyl ester hydrochloride수율 88%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of (N-t-butoxycarbonyl-N-methyl-amino)acetic acid p-nitrobenzyl ester (4.30 g, 133 mmol) (obtained as described in Reference Example 43(1)) was added a solution of 4N hydrogen chloride in 1,4-dioxane (4.3 ml) in an ice bath, and the mixture was stirred at room temperature for 2.5 hours. After checking the completion of the reaction, diethyl ether was added thereto and the reaction mixture was stirred for 30 minutes. The resulting reaction mixture was filtered and the obtained residue was washed with diethyl ether and dried to give sarcosine p-nitrobenzyl ester hydrochloride (3.04 g, yield 88%).

후처리

  1. additionwas added
  2. stirringthe reaction mixture was stirred for 30 minutes
  3. customThe resulting reaction mixture
  4. filtrationwas filtered
  5. washthe obtained residue was washed with diethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-e27e02e2e6ed459a9aa1d3e6ac0636d7
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07001897B2

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