Hydrochloric Acid → N~2~-Propan-2-ylglycinamide--hydrogen chloride (1/1)

To a solution of N-carbamoylmethyl-N-isopropyl-carbamic acid t-butyl ester (2.67 g, 12.3 mmol) (obtained as described in Reference Example 49(1)) in 1,4-dioxane (30 ml) was added a solution of 4N hydrogen chloride in 1,4-dioxane (30 ml) in an ice bath, and then the mixture was stirred at room temperature overnight. After checking the completion of the reaction, diethyl ether was added thereto and the reaction mixture was stirred for 30 minutes. The resulting mixture was filtered, and the residue was washed with diethyl ether and then dried under reduced pressure to give 2-isopropylaminoacetamide hydrochloride (1.82 g, yield 97%) as white crystals.

1. additionwas added
2. stirringthe reaction mixture was stirred for 30 minutes
3. filtrationThe resulting mixture was filtered
4. washthe residue was washed with diethyl ether
5. customdried under reduced pressure

ORD 기록

ord-579c2296d911401ebe0bc54fd581ec40

출처 데이터셋

uspto-grants-2006_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07001897B2