Glyoxylic Acid → HCID 11259991, 화합물

HRID 891832

반응식

HRID 891832 반응식
[C:1]([OH:5])(=[O:4])[CH:2]=O.[CH2:6]([S:12][S:13][CH2:14][C@H:15]([NH2:19])[C:16]([OH:18])=[O:17])[C@H:7]([NH2:11])[C:8]([OH:10])=[O:9].B([O-])([O-])[O-]>>[C:1]([CH2:2][N:11]([CH2:2][C:1]([OH:5])=[O:4])[C@H:7]([C:8]([OH:10])=[O:9])[CH2:6][S:12][S:13][CH2:14][C@H:15]([N:19]([CH2:15][C:16]([OH:18])=[O:17])[CH2:7][C:8]([OH:10])=[O:9])[C:16]([OH:18])=[O:17])([OH:5])=[O:4]

참가 물질

4

반응물 3

HCID 760Glyoxylic AcidHCID 26574BorateHCID 67678(-)-Cystine

생성물 1

HCID 11259991HCID 11259991, 화합물

실험 절차

The alternative route, relying on in solution phase synthesis of an intermediate product starts with addition of a large excess (40 times) of glyoxylic acid to L-cystine in an alkaline borate buffer. The intermediate product was thereafter, after pH manipulations and conductivity adjustment of the reaction mixture, purified with ion exchange chromatography to give N,N,N′,N′-tetrakis (carboxymethyl)-L-cystine.

후처리

  1. customThe alternative route, relying on in solution phase synthesis of an intermediate product
  2. customafter pH manipulations and conductivity adjustment of the reaction mixture, purified with ion exchange chromatography

출처 및 근거

ORD 기록
ord-ce089f0ba7b44eafb0e7bc10f2374c60
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07005071B2

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