Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Sulfate → 2-Bromo-7-ethoxynaphthalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Sulfate | HCID 6163 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 7-Bromo-2-naphthol | HCID 613827 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Bromo-7-ethoxynaphthalene | HCID 22240149 | 89% |
반응 단계
To a solution of 7-bromo-naphth-2-ol (1.0 g, 4.5 mmol, prepared according to patent WO 0146187 A1) in acetonitrile (10 ml) was added diethyl sulfate (1.04 g, 6.7 mmol), K2CO3 (0.92 g) and tetrabutylammonium bromide (10 mg). The reaction mixture was refluxed for 1 hour, poured on water and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and the solvent was removed under reduced pressure to provide 2-bromo-7-ethoxynaphthalene (89%), MS: m/e=252 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07005432B2 |
| 출처 데이터셋 | uspto-grants-2006_02 |
| ORD ID | ord-258293cb967e432aaa11dcbe01b4630c |
| 출처 메모 | uspto-grants-2006_02 |