Benzoyl Peroxide → (2-Bromomethyl-4-chloro-6-methyl-phenoxy)-acetonitrile
반응식
[Cl:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]([O:6][CH2:7][C:8]#[N:9])=[C:4]([CH3:13])[CH:3]=1.[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:4]1[CH:3]=[C:2]([Cl:1])[CH:11]=[C:10]([CH3:12])[C:5]=1[O:6][CH2:7][C:8]#[N:9]참가 물질
5
실험 절차
(4-Chloro-2,6-dimethyl-phenoxy)-acetonitrile (700 mg, 3.6 mmol, example 42), N-bromosuccinimide (510 mg, 2.9 mmol) and benzoyl peroxide (72 mg, 0.29 mmol) are heated at reflux in carbon tetrachloride (10 mL) for 16 h. The reaction is cooled, filtered and the filtrate is concentrated and purified by column chromatograpy (silica, 5% ethyl acetate in hexanes) to provide the title compound. MS (EI) 273, 275(M)+, Br pattern.
후처리
- temperatureThe reaction is cooled
- filtrationfiltered
- concentrationthe filtrate is concentrated
- custompurified by column chromatograpy (silica, 5% ethyl acetate in hexanes)
출처 및 근거
- ORD 기록
- ord-c2b5e3e6e2964249bf7e7f4a58340f60
- 출처 데이터셋
- uspto-grants-2006_02
- 특허 번호
- US07005440B1
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