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Methyl Salicylate → Methyl 2-[3-(quinolin-2-ylmethoxy)-benzyloxy]-benzoate

HRID 892184
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HRID 892184 반응식
Cl.Cl[CH2:3][C:4]1[CH:5]=[C:6]([CH:19]=[CH:20][CH:21]=1)[O:7][CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.C(=O)(O)[O-].[Na+].[C:27]([O:36][CH3:37])(=[O:35])[C:28]1[C:29](=[CH:31][CH:32]=[CH:33][CH:34]=1)[OH:30].[H-].[Na+].[Cl-].[NH4+]>CN(C=O)C.C(OCC)(=O)C.C(OCC)C>[N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:17]=[CH:18][C:9]=1[CH2:8][O:7][C:6]1[CH:5]=[C:4]([CH:21]=[CH:20][CH:19]=1)[CH2:3][O:30][C:29]1[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=1[C:27]([O:36][CH3:37])=[O:35]
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9

반응물 5

HCID 4133Methyl SalicylateHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 516892Sodium BicarbonateHCID 145017072-(3-Chloromethylphenoxymethyl)quinoline hydrochloride

생성물 1

HCID 22241562Methyl 2-[3-(quinolin-2-ylmethoxy)-benzyloxy]-benzoate

시약·촉매·용매 3

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

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온도
60 °C

실험 절차

The free base of 2-(3-chloromethyl-phenoxymethyl)-quinoline hydrochloride (540 mg, 1.7 mmol, example 49) is prepard by partioning the material between ethyl ether and sodium bicarbonate and drying the organic phase with magnesium sulfate. This material is then dissolved with methyl salicylate (260 mg, 1.7 mmol) in DMF (10 mL) at 0° C. and sodium hydride (60%, 65 mg 1.7 mmol) is added. The reaction is brought to room temperature for 15 min. and is then heated at 60° C. for 6 h. The reaction is cooled and partioned between ethyl acetate and a saturated ammonium chloride solution. The organic phase is dried over magnesium sulfate, filtered, concentrated in vacuo and purified by column chromatography (silica, 50 to 80% ether in hexanes) to provide the title compound; MS (ESI) 400 (M+H)+.

후처리

  1. dry with materialdrying the organic phase with magnesium sulfate
  2. temperatureThe reaction is cooled
  3. dry with materialThe organic phase is dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. custompurified by column chromatography (silica, 50 to 80% ether in hexanes)

출처 및 근거

ORD 기록
ord-d86e556c67334af399d111d12cb61b34
출처 데이터셋
uspto-grants-2006_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07005440B1

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