Formamide → HCID 15005406, 화합물
반응식
[CH:1]([NH2:3])=[O:2].Br[CH:5]([C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:6](=O)[CH3:7].C(=O)(O)[O-].[Na+]>ClCCl>[C:13]([C:12]1[CH:15]=[CH:16][C:9]([C:5]2[O:2][CH:1]=[N:3][C:6]=2[CH3:7])=[CH:10][CH:11]=1)#[N:14]참가 물질
5
실험 절차
A stirred, two-phase mixture of formamide (0.6 ml, 15 mmol) and 4-(1-bromo-2-oxopropyl)benzonitrile (0.8 g, 3.4 mmol) was heated to 120° for 2 hours. After cooling, dichloromethane (15 ml) and saturated aqueous sodium bicarbonate (10 ml) were added, the organic phase was separated, dried (magnesium sulphate) and the solvent removed under reduced pressure to yield 0.4 g of an amorphous yellow solid. The product was purified by silica gel chromatography, eluting with dichloromethane to yield the title compound (0.29 g, 47%) as a pale yellow solid, m.p. 120°-121° C.
후처리
- temperaturewas heated to 120° for 2 hours
- temperatureAfter cooling
- customthe organic phase was separated
- dry with materialdried (magnesium sulphate)
- customthe solvent removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-432de15b6c1e4ef09eeec18ab8da8498
- 출처 데이터셋
- uspto-grants-1992_06
- 특허 번호
- US05120747
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