1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide

HRID 892890노트

반응식

HRID 892890 반응식
Cl.C(N=C=NCCCN(C)C)C.[C:13]([NH:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH2:35])(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].[CH3:40][C:41]1([CH3:57])[O:46][CH:45]([C:47]([NH:49][CH2:50][CH2:51][C:52](O)=[O:53])=[O:48])[C:44]([CH3:56])([CH3:55])[CH2:43][O:42]1>C(Cl)Cl>[C:13]([NH:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH:35][C:52](=[O:53])[CH2:51][CH2:50][NH:49][C:47]([CH:45]1[C:44]([CH3:55])([CH3:56])[CH2:43][O:42][C:41]([CH3:57])([CH3:40])[O:46]1)=[O:48])(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

참가 물질

5

반응물 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 189385173-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acidHCID 42604663o-Oleoylaminoaniline

생성물 1

HCID 67796153N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide수율 82%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (211 mg) was added to a solution of 372 mg of 2-oleoylaminoaniline and 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid in 30 ml of methylene chloride under ice cooling. The mixture was stirred in situ for one night. The reaction mixture was washed with water and dried over anhydrous sodium sulfate, filtered and the filtate evaporation under vacuum to obtain the crude title products. Then, the residue obtained was subjected to silica gel column chromatography to obtain 500 mg of the title compound (yield: 82%).

후처리

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. filtrationfiltered
  4. customthe filtate evaporation under vacuum
  5. customto obtain the crude title products
  6. customThen, the residue obtained

출처 및 근거

ORD 기록
ord-79dd72c185834bb6be6210b6151eb400
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05120738

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