1,2,3,4-Tetrahydro-1-methylquinoline → 1,2,3,4-Tetrahydroquinoline

HRID 893061

반응식

HRID 893061 반응식
Cl.C[N:3]1[C:12]2[C:7](=[CH:8][C:9](N=O)=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1.CN1C2C(=CC=CC=2)CCC1>>[NH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1

참가 물질

3

반응물 2

HCID 681091,2,3,4-Tetrahydro-1-methylquinolineHCID 190990131-Methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride

생성물 1

HCID 694601,2,3,4-Tetrahydroquinoline

실험 절차

1-methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride ##STR25## The title compound is prepared from 1-methyl1,2,3,4-tetrahydroquinoline (obtained from 1,2,3,4tetrahydroquinoline by heating with trimethylphosphate (according to Huisgen et al., Chem. Ber. 92, 203 (1959)). The crude product is produced in the usual manner analogous to Examples 10 and 11 and purified on silica gel 60 (Merck) with isopropanol/n-butylacetate/water=5:3:2. The title compound is obtained by dissolving this in acetone after addition of ethereal hydrochloric acid, m.p. 123°-124° C. (decomp.), TLC: silica gel 60, mobile phase: isopropanol/n-butylacetate/water=5:3:2, Rf =0.7.

출처 및 근거

ORD 기록
ord-dae7ceedec2d48afba15df48ed72fbf0
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05122244

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