1-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → 1-Benzyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
반응식
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20]C)=[C:15]([O:18]C)[CH:16]=2)[CH2:11][CH2:10][NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Br>[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:20])=[C:15]([OH:18])[CH:16]=2)[CH2:11][CH2:10][NH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
3
실험 절차
Treat 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (10 g) with 48% HBr (100 mL) and heat the mixture at reflux under nitrogen for 2 h. Cool the mixture to room temperature and allow crystals to form overnight. Collect the crystals and wash with cold ethanol to give 7.5 g of the title compound as its HBr salt, mp=233°-236° C.
후처리
- temperatureheat the mixture
- temperatureat reflux under nitrogen for 2 h
- customto form overnight
- customCollect the crystals
- washwash with cold ethanol
출처 및 근거
- ORD 기록
- ord-c9e1a9cce5a54e46a15f151c95fbf8b9
- 출처 데이터셋
- uspto-grants-1992_06
- 특허 번호
- US05124337
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