Methanol → 4-(2-Methoxyethyl)phenol

반응식

CO[C:3](OC)([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[CH:4]=[O:5].[CH3:15]O>>[CH3:15][O:5][CH2:4][CH2:3][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

참가 물질

반응물 2

HCID 887Methanol

HCID 197888474-Hydroxyphenylglyoxal dimethyl acetal

생성물 1

HCID 925164-(2-Methoxyethyl)phenol수율 47%

실험 절차

The procedure of Example 2 was repeated with a solution of 2.00 g (10.2) mmol) 4-hydroxyphenylglyoxal dimethyl acetal in 10 g methanol containing 0.37 g (10.2 mmol) hydrogen chloride and a 0.20 g dry 10% Pd/C catalyst being reacted with hydrogen gas pressurized at 50 psig at 25° C. A 47% yield of 4-(2'-methoxyethyl)phenol was obtained.

후처리

dry with materiala 0.20 g dry 10% Pd/C catalyst
custombeing reacted with hydrogen gas
custompressurized at 50 psig at 25° C

출처 및 근거

ORD 기록: ord-d12f1b3bc7654c74aa26163577d4b7bc
출처 데이터셋: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05124489

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