Sodium Hydroxide → 2-(4-Bromophenoxymethyl)benzoic acid
반응식
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][C:8]2[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:18][CH:19]=1참가 물질
4
실험 절차
Reflux 90 gm. of the crude methyl o-(p-bromophenoxymethyl)benzoate from Step B for 1 hour in a mixture of 500 cc. of methanol and 250 cc. of 10% aqueous sodium hydroxide. Evaporate the methanol and dilute the resulting aqueous solution with an equal volume of water. Acidify with conc. hydrochloric acid. Separate the solids by filtration, wash with water and dry in vacuo to obtain the title product (m.p. 183°-185° C.).
후처리
- temperatureReflux 90 gm
- customEvaporate the methanol
- additiondilute the resulting aqueous solution with an equal volume of water
- customSeparate the solids
- filtrationby filtration
- washwash with water
- customdry in vacuo
출처 및 근거
- ORD 기록
- ord-fe23260d7d594c14b618cde616bca14a
- 출처 데이터셋
- uspto-grants-1981_08
- 특허 번호
- US04282365
반응 노트
불러오는 중…