Acetic Acid → Olopatadine Impurity 17
반응식
C(C1[CH:18]=[CH:17][C:6]2[O:7][CH2:8][C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[C:11](=[O:12])[C:5]=2[CH:4]=1)#N.Cl.[C:20]([OH:23])(=[O:22])[CH3:21]>O>[O:12]=[C:11]1[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[CH2:8][O:7][C:6]2[CH:17]=[CH:18][C:21]([C:20]([OH:23])=[O:22])=[CH:4][C:5]1=2참가 물질
5
실험 절차
Reflux 27.3 gm. of 2-cyano-6,11-dihydro-11-oxodibenz[b,e]oxepin in a mixture of 300 cc. of 37% aqueous hydrochloric acid and 300 cc. of glacial acetic acid for 24 hours. Cool, dilute with water and separate the solids by filtration in order to obtain the title product (m.p. 250° C. dec.).
후처리
- temperatureReflux 27.3 gm
- temperatureCool
- customseparate the solids
- filtrationby filtration in order
출처 및 근거
- ORD 기록
- ord-22b50447770248b19f472dbeb7d6785f
- 출처 데이터셋
- uspto-grants-1981_08
- 특허 번호
- US04282365
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